As with the Champions League, the competition has been revamped this season, with the old 32-team, eight-group format replaced by a single, 36-team league phase.
Each of the competing clubs has been assigned two sides from each of the four pots, resulting in eight games - four home and four away - to be played between September and the end of January.
Exact dates and kick-off times for these fixtures, as well as their order, will be confirmed on Saturday, but scroll down to see who the Reds will take on this season...
HOME GAMES
Rangers
PAOK
Bodo/Glimt
Twente
The headline Old Trafford fixture sees us host Rangers for the first time since 2010, in an all-British affair.