Eric Bailly misses out on the substitutes bench, with back problems presenting an issue for the Ivorian in the last few days. Teenager Alejandro Garnacho also makes the bench once more, following his debut against Chelsea just nine days ago.
United: De Gea; Telles, Lindelof, Varane, Dalot; Matic, McTominay; Elanga, Mata, Fernandes (c), Ronaldo.
Substitues: Henderson, Fernandez, Jones, Maguire, Wan-Bissaka, Fred, Lingard, Cavani, Garnacho.
Brighton: Sanchez; Cucurella, Dunk (c), Veltman; March, Bissouma, Caicedo, Trossard; Gross, Mac Allister, Welbeck.
Substitues: Steele, Lamptey, Webster, Maupay, Lallana, Alzate, Duffy, Offiah, Ferguson.