The league meeting was due to take place at Leigh Sports Village on Sunday 27 April, but has been moved due to the Blues' UEFA Champions League semi-final second leg against Barcelona being added to the schedule for that weekend.
United v Chelsea will now be played three days later, on Wednesday 30 April, and kick off at 20:15 BST.
The match will be broadcast live from LSV in the UK on Sky Sports.
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It's set to be an intriguing late-season duel that will see two of the division's top three sides go head-to-head, less than two weeks before the end of the campaign.