The Germans, coached by the highly rated Julian Nagelsmann, made it to the semi-finals of the competition last year and, like United, got off to a winning start in this season’s edition - beating Istanbul Basaksehir 2-0 in Leipzig last week.
As Europe’s top-tier tournament returns to Old Trafford, our match preview tells you all you need to know…
ESSENTIAL INFO
Kick-off in Manchester takes place at 20:00 GMT and fans in the UK can watch the match live on BT Sport. Supporters can also follow our rolling updates on ManUtd.com and within our Official App, while MUTV will provide live build-up, radio commentary and reaction from 18:55 GMT.