Jose Mourinho's Reds have been working towards this fixture all summer by taking part in six friendlies, against Club America, San Jose Earthquakes, AC Milan, Liverpool, Real Madrid and Bayern Munich.
Our match preview is here to get you up to speed before the return to the Theatre of Dreams. Let's start with the basics...
WHAT DO WE KNOW ABOUT LEICESTER?
The Foxes registered a series of mixed results over the summer, but notably won at the weekend and they now plan to start at Old Trafford on a positive note.
Claude Puel's team finished ninth last season and replicating the form that underpinned their 2016/17 title success is surely the ambition.