The Blues, like United, finished in the top four last season and, after spending big in the summer, are hoping to mount a title challenge this time around.
Meanwhile, Ole Gunnar Solskjaer will be looking for his side to build on the recent impressive victories over Newcastle United and Paris Saint-Germain, against a Chelsea team he has got the better of several times before.
Here’s everything you need to know before Saturday’s big game…
ESSENTIAL INFO
Kick-off in Manchester takes place at 17:30 BST and fans in the UK can watch the match live on Sky Sports Main Event and Sky Sports Football.