Ole Gunnar Solskjaer's men will hope to repeat the success we had the last time we participated in the competition, back in 2016/17, when we beat Ajax to win the title at the Friends Arena in Stockholm. But first we have to get out of a group that also includes AZ Alkmaar and Partizan Belgrade.
Ahead of Thursday's kick-off, here is everything you need to know...
HOW CAN I FOLLOW THE GAME?
MUTV subscribers will be able to watch an extensive build-up to the game via the channel's Match Day show from 18:30 BST, followed by comprehensive live radio commentary.