The home fans will be hoping for three points to boost our bid for a top-four place after successive 1-1 draws with Burnley and Southampton.
There are two changes to the XI that started the Saints encounter at the weekend.
The boss has opted to recall Fred into the midfield after he was forced to isolate due to contracting COVID-19. The Brazilian replaces Paul Pogba, who is being treated carefully following his injury lay-off.
Anthony Elanga is also included in a wide role after coming off the bench on Saturday. The youngster takes the place of fellow Academy graduate Marcus Rashford, who is the chief attacking option among the substitutes.