The boss has made four changes from the 6-0 win at Tranmere for the 19:45 GMT kick-off, which you can follow in our live scorecentre.
David De Gea replaces Sergio Romero in goal, Aaron Wan-Bissaka and Brandon Williams are drafted in to what is presumably a five-man defence, and Fred replaces Andreas Pereira in midfield.
Mason Greenwood and Anthony Martial will be asked to provide the main attacking threat.
The Reds are trailing 3-1 from the first leg at Old Trafford, when Marcus Rashford's second-half strike reduced the deficit.
Away goals do not count and, if the scores are level after 90 minutes, the game will go straight to penalties.