The Reds approach the Old Trafford encounter looking to take a lead to the Italian capital in next Thursday's return game.
At the same time, Villarreal meet Arsenal in the other last-four tie.
David De Gea gets the nod to keep goal, as he did in the previous round's games against Granada. The side is, pretty much, as expected with Scott McTominay and Fred forming the axis in the midfield, allowing Paul Pogba to move further forward.
That means Mason Greenwood starts on the bench, with the experienced Edinson Cavani chosen to lead the line.