Sheffield United were runners-up in last season’s EFL Championship and Paul Heckingbottom’s side have struggled to adjust to the higher division so far, drawing one and losing seven of their eight outings.
The Reds, meanwhile, are looking for a 10th straight win in Premier League games against teams that went up the season before.
Erik ten Hag’s men have already claimed three points on the road against last season’s second-tier champions, with Bruno Fernandes’s superb volley settling a tight encounter at Burnley last month.
The Dutchman has a 100 per cent record in such fixtures, masterminding six victories out of six from games with Bournemouth, Fulham and Nottingham Forest in 2022/23.