United are the first club in the competition's history to achieve the feat, doing so on our first visit to the Brentford Community Stadium, the 55th Premier League ground we've finished as victors.
Here’s all you need to know about those 300 victories and keep your eyes peeled for further features over the coming days…
WE'VE ALMOST WON EVERYWHERE
Forty-nine clubs other than United have played Premier League football since 1992 and we’ve beaten 47 of them away from home. Huddersfield Town won four home points against the Reds during their two seasons in the big time, while Swindon Town's only top-flight campaign featured a 2-2 draw with Sir Alex Ferguson’s reigning champions at the County Ground.