Ahead of the game, which kicks off at 19:00 GMT and will be shown live on MUTV, the Reds are in second spot, one point behind the unbeaten Hammers.
The London club secured a 2-2 draw at Old Trafford earlier in the season and this will be another big test for Neil Wood's team, who hope to have James Garner and Dylan Levitt available after being sidelined recently.
Ole Gunnar Solskjaer has been hoping the likes of Eric Bailly and Tim Fosu-Mensah get a run-out at this level after recovering from knee operations but they will not feature at the Chigwell Construction Stadium.