The journey south offers Neil Wood's in-form youngsters the chance to register a fourth successive win in Premier League 2, following the entertaining 4-2 triumph over Tottenham at the weekend.
Arnau Puigmal netted twice, with Shola Shoretire and Anthony Elanga also on the scoresheet against Spurs.
“We played some good football,” said lead coach Wood afterwards. “We're really pleased with the goals that we scored.”
Once again, Friday's match will be shown live on MUTV, with the Hammers the other side to gain promotion with the Reds last season.
“The lads enjoy it as well as they know when they're doing the right things,” added Wood.