The Reds will begin the campaign with an away game at Arsenal on 6 August before a first home encounter, with Crystal Palace, on the following Friday.
There is a sizeable gap in the calendar due to the World Cup, with a Manchester derby on 5 November pencilled in as provisionally the final outing of 2022. The opening game of the New Year is not until 14 January, when Liverpool provide the opposition at Leigh Sports Village.
Please note, however, that all fixtures are subject to change.
AUGUST
Sat 6: Arsenal (A) 13:00 (Boreham Wood)
Fri 12: Crystal Palace (H) 19:00 (Leigh)
Fri 19: Everton (A) 19:00 (Southport)
Fri 26: Fulham (H) 19:00 (Leigh)
SEPTEMBER
Sat 3: Liverpool (A) 14:00 (Liverpool Academy)
Fri 9: Leicester (H) 19:00 (Leigh)
Fri 16: West Ham (H) 19:00 (Leigh)
Fri 26: Fulham (H) 19:00 (Leigh)
OCTOBER
Sat 8: Brighton (H) 13:00 (Leigh)
Sat 15: Chelsea (A) 12:00 (Kingsmeadow Stadium)
Sun 23: Wolves (H) 13:00 (Leigh)
Sat 29: Tottenham (A) 12:00 (Lamex Stadium)
NOVEMBER
Sat 5: Manchester City (H) 13:00 (Leigh)
JANUARY
Sat 14: Liverpool (H) 13:00 (Leigh)
Fri 20: West Ham (A) 19:00 (Rush Green)
Fri 27: Blackburn Rovers (H) 19:00 (Leigh)
FEBRUARY
Sat 11: Everton (H) 13:00 (Leigh)
Mon 20: Crystal Palace (A) 19:00 (Crystal Palace Training Ground)
Mon 27: Wolves (A) 19:00 (Aggborough)
MARCH
Sun 5: Chelsea (H) 13:00 (Leigh)
Sat 18: Manchester City (A) 15:00 (TBC)
Fri 31: Arsenal (H) 13:00 (Leigh)
APRIL
Mon 17: Leicester City (A) 19:00 (Leicester City Training Ground)
Sun 23: Brighton (A) 16:00 (Amex Elite Performance Centre)
Fri 28: Tottenham (H) 19:00 (Leigh)