The Reds have three home games in the European competition, with an exciting clash against Monaco set to be staged at Old Trafford.
That big night for the youngsters is on Friday 11 November, with kick-off at 19:00 GMT.
First up, we welcome Sparta Prague to the J Davidson Stadium in Altrincham on 26 October (19:00 BST), and there is a pre-Christmas clash with PSV Eindhoven, at Leigh Sports Village, on Monday 19 December (19:00 GMT).
In terms of Premier League 2 action, the home game with Wolves has been switched to Carrington on Saturday 22 October (14:00 BST), and will be played behind closed doors.