The County Ground hosts the 19:00 GMT kick-off and the match is being shown live on MUTV and the United App for viewers in the UK and Ireland.
Adam Lawrence's side reached this stage with a 1-0 victory over Derby County at Old Trafford last month. Ethan Williams, who opened the scoring in the team's most recent outing, Saturday's 3-1 win at Newcastle United, grabbed the only goal of the game.
Ashton Missin and Jayce Fitzgerald also found the net at the weekend, as we stretched our 100 per cent record in the Under-18 Premier League North to 11 games this season.