Adam Lawrence's side won the national title last term, beating southern champions Chelsea in the final, but, of course, the personnel changes with the older players moving up to the Under-21s.
United kick things off on 17 August with a home game against Wolves, before the mini-Manchester derby away to Manchester City and a clash with Liverpool at Carrington.
Please note that all fixtures are still subject to change.
August
17: Wolves (H)
24: Manchester City (A) 11:30 BST
31: Liverpool (H)
September
14: Newcastle United (A) 12:30 BST
21: Middlesbrough (A) 12:30 BST
28: Blackburn Rovers (H)
October
19: Sunderland (A) 12:30 BST
26: Nottingham Forest (H) 12:00 BST
November
2: Leeds United (A) 12:00 GMT
9: Everton (H)
30: Stoke City (A)
January
18: Derby County (H) 12:00 GMT
25: Wolves (A)
February
1: Manchester City (H)
8: Liverpool (A)
15: Newcastle United (H) 12:30 GMT
22: Blackburn Rovers (A)
March
1: Middlesbrough (H) 12:00 GMT
8: Derby County (A) 12:00 GMT
29: Sunderland (H) 12:30 GMT
April
5: Leeds United (H)
12: Nottingham Forest (A) 12:00 GMT
26: Everton (A)
May
3: Stoke City (H)
All fixtures start at 11:00 unless otherwise stated, and are subject to change.