The 32-team competition, originally launched in 2014, pits the top 16 finishers in Premier League 2 against 16 invited international clubs. The PLIC begins with eight groups, each made up of four English and four international clubs.
All games are played between Premier League 2 and international clubs only, and are always hosted in England. The top two sides from each group progress.
United's international opponents this season are Hertha Berlin, Nordsjaelland, PSV Eindhoven and Sparta Prague.
With the U21s' regular home ground of Leigh Sports Village unavailable, our October date against Hertha Berlin is to be played at Salford City.