Manchester United's Under-21s were condemned to a first defeat in six Premier League 2 matches on Monday night, having been edged out 1-0 by Fulham at Leigh Sports Village.
Callum Osmand's strike, 10 minutes after half-time, proved to be the difference as the Cottagers left the North West with all three points from the encounter under the lights.
Teenage defender Ayden Heaven, who joined United's senior squad after signing from Arsenal earlier this month, made his first appearance for the club on the evening, completing a pre-planned 45-minute outing.
James Scanlon went close to finding the breakthrough in the first half.