Both players sustained knocks in the Emirates FA Cup tie against Fulham on Sunday and did not train with the main group at Carrington, in advance of the flight to Spain for Thursday's Europa League round-of-16 first leg at Real Sociedad.
They were subsequently left out of the 18-man travelling squad for the 17:45 GMT kick-off and, although the competition is so important in the context of our season, the head coach is not gambling on the pair, with Arsenal to come at the weekend in the Premier League, before the second leg of this tie at Old Trafford.