Jose Mourinho has made eight changes to his starting line-up to face Burnley at Turf Moor (kick off 14:15 BST) as the Reds look to close the gap on rivals Manchester City to just one point.
After progressing to the semi final of the Europa League on Thursday, the Reds were dealt a double injury blow with the news that Marcos Rojo and Zlatan Ibrahimovic both sustained 'significant knee ligament damage' so the United boss has been forced to shuffle his pack further today.
Daley Blind, who replaced Rojo on Thursday, starts alongside Eric Bailly in the heart of United's defence, whilst Matteo Darmian comes in at right back for Antonio Valencia.