Captain Bruno Fernandes is absent through suspension, serving a one-game ban for the red card he received during the 3-3 draw with FC Porto, and Jonny Evans also misses out.
"The players who are available have to do the job and they are capable of doing the job," explained Ten Hag to reporters in Istanbul.
"I think we have enough players in the team that are so experienced. Our team is so experienced. We’ve faced such situations more often. I think we’re looking forward, I think it will be a great ambience that’s fuel for the team and it’s a real challenge, it’s a motivation, it’s really good for us.