The Reds meet Roy Hodgson's men for the second time this week, following the 3-0 victory at Old Trafford in Tuesday's Carabao Cup third-round tie.
Lisandro Martinez and Sergio Reguilon are both injured, as communicated on Friday, while Antony is still unavailable, even though he is returning to training.
There are four changes to the XI on duty in midweek.
Victor Lindelof is in at centre-back for Harry Maguire, with Sofyan Amrabat set to continue of the left-hand side of the defence. Mason Mount and returning skipper Bruno Fernandes could be interchangeable in terms of their positions, while Marcus Rashford replaces Alejandro Garnacho, scorer of the opener in the cup tie, on the left wing.