The boss has acknowledged that the loss of Lisandro Martinez with a knee injury is a "setback" but says he has other options for the central defensive positions.
Aaron Wan-Bissaka appears to be a real doubt and Mason Mount remains on the sidelines.
Tyrell Malacia and Anthony Martial are also absentees, as the Reds look to close the gap on Unai Emery's team to five points by completing the double over the Midlanders, who lost at home to Chelsea in the Emirates FA Cup on Wednesday.
"It is a setback, of course," the manager said, in relation to Martinez's injury.