Jonny Evans and Raphael Varane had already been ruled out of the 17:30 BST kick-off at the Vitality Stadium.
The experienced pair are joined by fellow defenders Lisandro Martinez, Luke Shaw, Tyrell Malacia and Victor Lindelof on the sidelines. Striker Anthony Martial also remains out.
Scott McTominay missed the 2-2 draw with Liverpool and seems unlikely to be fit in time but fellow homegrown star Marcus Rashford has trained and may be available to feature.
"Scott? I dont think so," the manager said at his press conference, when asked about McTominay's involvement. "We have training, so we have a day and he will push.