The Reds kick domestic football off again, with a 12:30 BST start at St Mary's on the horizon, against Russell Martin's Saints.
The early assignment comes on the back of an international break that has included several United men performing on different continents in midweek, and the manager will be assessing his options for the trip south.
New boy Manuel Ugarte will be available, despite only coming back from South America today (Thursday), while Luke Shaw and Rasmus Hojlund miss out again.
"Rasmus Hojlund and Luke Shaw, they are progressing very well, but are not ready for this game," Ten Hag said at his press conference.