The Reds travel to the Premier League leaders looking to prevent the Merseysiders from maintaining their 100 per cent record at home this term.
Anfield has been a fortress for the hosts and a far from happy place for United to go in recent seasons, but there is some positive news on the injury and illness front in advance of Sunday's 16:30 GMT kick-off.
United captain Bruno Fernandes is suspended after accruing five yellow cards in the league, following his booking against Bournemouth last weekend.
Harry Maguire has been ruled out after being withdrawn in the first half of the defeat to Bayern Munich in the UEFA Champions League but his fellow England defender Luke Shaw will hopefully be available, despite going off at half-time on Tuesday.