The French international went off on the hour-mark after stretching awkwardly as he tried to clear the ball before Pierre-Emerick Aubameyang could get away.
While Varane was able to walk off the pitch with the club physio and doctor, he was crying as he did so signifying the severity of the injury.
Ten Hag told reporters after the game: "It is difficult to say how it is now because it is so soon after the game.
"We have to wait 24 hours and then we will know what it is."
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