The Reds are looking to extend our winning sequence at Old Trafford, in all competitions, to 14 games, with manager-less Leeds coming to town for the first of two consecutive meetings with the Yorkshiremen.
Casemiro is suspended for the game, as he sits out the first of three Premier League fixtures following his red card, as a result of VAR intervention, against Crystal Palace on Saturday. The influential midfielder also misses the Elland Road clash at the weekend and home match with Leicester City.
Casemiro's fellow Brazilian, Antony, is also out of action, presumably after being hurt in the challenge by Jeffrey Schlupp that sparked the confrontation leading to the sending off.