The manager has been forced into changes and it remains to be seen whether Jonny Evans or Lisandro Martinez takes on left-back duties, with Noussair Mazraoui on the bench, and Diogo Dalot expected to switch to his more familiar right-sided role.
Casemiro is back to partner Christian Eriksen in the engine room, in the absence of Kobbie Mainoo, with Manuel Ugarte another not risked as a starter, as he is among the substitutes.
Matthijs de Ligt is another alteration to the team that drew 0-0 at Aston Villa before the international break.
Youngster Jack Fletcher is part of a senior matchday squad for the first time, with Darren's son the other midfield option, alongside Ugarte.