With Casemiro suspending following his fifth booking of the season in midweek against the Eagles, Scott McTominay has been brought into the midfield alongside Christian Eriksen.
New signing Wout Weghorst continues in attack following his debut at Selhurst Park on Wednesday evening, with the trio of Marcus Rashford, Bruno Fernandes and Antony supporting the Dutchman.
Arsenal have posted just one loss in the Premier League thus far this season, a 3-1 defeat against United at Old Trafford back in September. Bidding to make it a domestic double this afternoon, the Reds could climb to third with victory in the capital.