The Old Trafford tie, which kicks off at 20:00 BST, must be decided on the night and will go straight to penalties, if level after 90 minutes.
However, the Reds will hope to clinch a second successive victory, following the impressive 3-0 win at Southampton at the weekend and the boss has selected a strong line-up, despite a raft of alterations.
The manager has made eight changes from Saturday's game at St Mary's Stadium and hands a first start, and home appearance, to summer signing Manuel Ugarte.
The Uruguay international could partner Toby Collyer in midfield, as the youngster is included in an XI for the first time in his senior career.