Ten Hag's men are out to end Arne Slot's 100 per cent start to life as Anfield boss and the atmosphere is certain to be electric at Old Trafford.
New signing Manuel Ugarte was not registered in time to play, while Mason Mount has been ruled out due to injury.
Summer signings Matthijs De Ligt and Joshua Zirkzee make their first starts for the Reds, after coming off the bench in our two opening games, against Fulham and Brighton & Hove Albion.
Alejandro Garnacho is also introduced to the line-up, with Amad, our scorer last time out, making way.