Andre Onana and Mason Mount make their first competitive appearance for the Reds, following their summer moves from Internazionale and Chelsea respectively.
Mount could play deep in midfield, alongside Casemiro, although skipper Bruno Fernandes is another option to fill that role.
Aaron Wan-Bissaka gets the nod at right-back, ahead of Diogo Dalot, with Alejandro Garnacho starting on the left wing after his impressive display in the friendly win over Lens.
Dean Henderson is on the bench - his last appearance for the club was in early February 2022, in an Emirates FA Cup tie with Middlesbrough.