The Reds are looking to get back on track after the disappointing pre-Christmas defeat at West Ham United, and striving to provide some cheer to the home supporters.
Ten Hag hoped Raphael Varane would be well enough to return to the heart of the defence, and the Frenchman partners Jonny Evans, with Diogo Dalot back from his ban and likely to play at left-back.
Kobbie Mainoo makes his first league start at Old Trafford, while the attacking line-up will be interesting, with Marcus Rashford presumably starting on the right.
Luke Shaw and Sofyan Amrabat are absent due to minor issues, as Erik makes four changes from the XI on duty at West Ham, with Christian Eriksen in from the outset after his comeback at the London Stadium.