The Reds head to the Midlands searching for a first league win since the 3-0 win over Southampton on 14 September.
Our opponents, Aston Villa, fly into the match high on Wednesday night's 1-0 victory over Bayern Munich in the Champions League, and are unbeaten since a 2-0 home defeat to Arsenal back in August.
Following Thursday's madcap 3-3 draw against FC Porto in Europe, Ten Hag has made the following four adjustments to the starting XI that began in Portugal.
There are arguably two bits of headline news, the first being Kobbie Mainoo's return to the line-up.