The vast majority of the 52,000 people inside Galatasaray's ground will be baying for a home win, a result which would eliminate the Reds from contention for the Champions League knockout stages.
But, after seeing how his players can cope in difficult surroundings at Everton on Sunday, Ten Hag has a blueprint for approaching the game.
Here, in an interview with MUTV's Zarah Connolly, he previews the occasion, while discussing the involvement of several Reds, including the returning Rasmus Hojlund...
Erik, off the back of such a great performance and result against Everton, how was training and is there a good feeling around the squad?