A start for David De Gea secures his place in United's top 10 all-time appearance makers outright, as he plays his 511th game for the Reds tonight.
The boss has opted to rotate his defence from the four who started Tuesday's Premier League win, bringing Raphael Varane back into the starting line-up to partner Luke Shaw who will shift into a central role once again.
Diogo Dalot and Tyrell Malacia get the nod as the two full-backs, with Aaron Wan-Bissaka among the substitutes.
"He [Shaw] did really well as a centre half," Ten Hag told ITV prior to kick-off.