The boss has recalled Lisandro Martinez after he was suspended for the Nou Camp clash, which finished 2-2 to leave things delicately poised for the Old Trafford return.
The World Cup winner replaces Luke Shaw beside Raphael Varane, with Shaw shifting to left-back and Tyrell Malacia named among the substitutes, alongside the likes of Marcel Sabitzer, Scott McTominay and fit-again Antony.
It looks like a fluid frontline again and there is every chance Wout Weghorst will drop deeper to allow Marcus Rashford to push into central areas, with Bruno Fernandes also capable of performing on the right, as he has done recently.