The Reds manager reacted to the 4-0 loss at Brentford last time out by ringing the changes for the Old Trafford encounter, including two in defence.
Raphael Varane starts alongside Lisandro Martinez, with Tyrell Malacia drafted in for Luke Shaw at left-back.
Bruno Fernandes takes over the captaincy with Harry Maguire on the bench.
Scott McTominay replaces Fred and Anthony Elanga is promoted into the XI after coming on as a substitute at Brentford.
Cristiano Ronaldo makes way and is waiting in the wings, along with Anthony Martial, following his injury lay-off.
The boss appears determined to press the visitors from the outset, explaining why Ronaldo starts on the bench.