Anthony Martial comes in to lead the line for the Reds in attack at Old Trafford, replacing the injured Marcus Rashford after he was injured during our 2-0 success over Everton on Saturday.
Casemiro and Raphael Varane also both returning to the starting XI for the visit of the Andalusians in M16, with the pair replacing Scott McTominay and Harry Maguire.
Christian Eriksen - who returned to action as a substitute against the Toffees - is again on the bench, whilst young Academy goalkeeper Radek Vitek is also named in our matchday squad, for the second time this season.