The Reds need only a point to secure qualification for the next phase of the competition but still have designs on toppling leaders Real Sociedad, and avoiding a side that has dropped out of the Champions League in the play-offs in 2023.
The boss has fielded a strong line-up, with Victor Lindelof replacing injured centre-back Raphael Varane, and Tyrell Malacia in for left-back Luke Shaw. Teenager Alejandro Garnacho makes his maiden start, with Cristiano Ronaldo also back to spearhead the attack, as Marcus Rashford and Jadon Sancho drop to the bench.
Fit-again Harry Maguire and Donny van de Beek are also among the substitutes.