New boy Antony is in from the off, replacing Anthony Elanga in the starting XI.
Deadline-day signing Martin Dubravka has also been named in the matchday squad, as one of the substitutes.
United's formidable back four of Diogo Dalot, Raphael Varane, Lisandro Martinez, and Tyrell Malacia retain their places on the back of two successive clean sheets.
Bruno Fernandes will once again retain captain duties with Harry Maguire named on the bench.
Sancho, whose goal helped us earn the three points at Leicester, also keeps his place.