Mason Mount has been ruled out of Manchester United's Carabao Cup quarter-final with Tottenham, while Noussair Mazraoui is a doubt for Thursday's 20:00 GMT kick-off.
Both players were substituted during the Manchester derby victory at the weekend, with Ruben Amorim admitting afterwards he had concerns over their fitness.
The head coach provided an update on the pair in his pre-match interview with MUTV's Mark Sullivan on Wednesday.
"Mason Mount is not available," Ruben stated. "He has an injury. Nous, we will see today. The rest of the squad are ready to play the game.
"We have to asses all the players and try not to get a lot of injuries.