Manchester United manager Jose Mourinho is set to name his side to face Watford at Vicarage Road.
The Reds are in action in the 12:00 BST kick-off and out to make up ground after wins for Manchester City, Everton, Arsenal and Liverpool left United sixth in the table. Victory would take Mourinho's men up to third and that must be the aim after the derby defeat to City last time out in the Premier League.
There were eight changes for the midweek loss at Feyenoord with Luke Shaw, Antonio Valencia and Wayne Rooney remaining in Manchester.