The two clubs have already played each other twice in the league this season, as well as in the Carabao Cup, resulting in three Reds victories.
However, the west London outfit head into this weekend's tie with 48 hours extra rest and recovery, following their 1-0 win over Norwich City on Tuesday, which is arguably a slight advantage.
So, would you alter our squad with that in mind? Would you leave regular starters on the bench?
On MUTV Group Chat this week, former midfielder Darren Fletcher admitted the extra couple of hours of rest may have an impact on Ole's selection.