The Reds go into the 15:00 GMT kick-off at Old Trafford on the back of a 3-1 win at Brentford and it's a fixture which allows Ralf's men the chance to leapfrog the Hammers in the table with a victory, ahead of the international break causing a pause in domestic action.
Rangnick was without the likes of Luke Shaw, Aaron Wan-Bissaka, Paul Pogba, Jadon Sancho and Edinson Cavani for the midweek trip to London, while Scott McTominay was substituted late on after receiving a painful knock to his back.
"Jadon didn't train because he still asked to be able to not train," said the boss in his press conference.