The Reds must respond to a turbulent weekend as the 4-1 defeat to Watford led to Ole Gunnar Solskjaer being replaced as manager, with Carrick entrusted with caretaker duties and helping the side maintain top spot in Group F of the Champions League.
Victory in Spain would ensure qualification for the knockout stages next year and provide a timely boost ahead of Sunday's assignment at Premier League leaders Chelsea.
Luke Shaw left the field with concussion at Vicarage Road, while strikers Edinson Cavani and Mason Greenwood were also absent for the defeat to the Hornets. France duo Raphael Varane and Paul Pogba are still sidelined as Carrick will have plenty to ponder regarding his line-up.