The Sweden centre-half has not taken to the pitch since our final pre-season match against Liverpool in South Carolina, where he played 45 minutes before being taken off as a precaution.
Speaking to the media before our trip to Sussex, the manager confirmed that Lindelof would not be part of our matchday squad due to a problem with his toe.
The Reds are already without left-backs Luke Shaw and Tyrell Malacia, while summer signing Leny Yoro is expected to be absent for a further two months due to a broken metatarsal.
Striker Ramus Hojlund also remains unavailable after suffering a hamstring injury.